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Chemical Formula: C₁₅₂H₂₅₂N₄₄O₄₂
Molecular Weight: ~3,368 g/mol
CAS Number: 446036-97-1
Structure: 29–amino acid mitochondrial-derived peptide with four strategic amino acid substitutions to enhance stability and biological activity
Form: Lyophilized powder
Solubility: Soluble in sterile water or aqueous buffer solutions
Stability: Stable when stored frozen; limited stability after reconstitution
Half-Life: Short circulating half-life in vivo (rapid peptide clearance)
Storage: Store refrigerated at 36–46°F (2–8°C); protect from light and moisture
Regulates nuclear and mitochondrial communication to improve metabolic adaptation
Activates AMPK signaling to enhance glucose uptake and fatty acid oxidation
Improves cellular response to metabolic stress and nutrient fluctuations
Supports improved mitochondrial respiration and energy production
Studied for improving insulin sensitivity and glucose metabolism in preclinical models
Investigated for reducing fat accumulation and improving lean mass preservation
Explored for enhancing endurance capacity and metabolic response to physical stress
Evaluated for improving mitochondrial function and reducing age-related metabolic decline in research models
Research demonstrates MOTS-c’s potent effects on metabolic health markers:
Enhances insulin sensitivity in experimental models
Improves glucose uptake and utilization in muscle tissue
Reduces fasting glucose and insulin resistance markers
Supports balanced energy homeostasis
Studies reveal MOTS-c’s influence on cellular energy pathways:
Promotes mitochondrial biogenesis and respiratory capacity
Enhances oxidative metabolism in skeletal muscle
Increases ATP production efficiency
Reduces metabolic stress under nutrient challenge
Research indicates heart and systemic metabolic benefits:
Supports improved lipid profiles in animal models
Reduces adiposity and ectopic fat accumulation
Protects against diet-induced metabolic dysfunction
Improves overall cardiometabolic risk markers
Studies demonstrate physical performance enhancements:
Increases exercise capacity and endurance in rodent models
Enhances skeletal muscle function
Improves fatigue resistance
Promotes favorable muscle energy dynamics
Research shows immunometabolic and stress-related benefits:
Reduces pro-inflammatory cytokine expression
Modulates stress response pathways
Protects cells from oxidative damage
Supports overall cellular resilience
MOTS-c has demonstrated favorable tolerability in preclinical and early research studies at evaluated doses.
Possible temporary effects may include mild injection site irritation, flushing, or short-term fatigue.
As a regulator of energy metabolism, rapid changes in dosing may temporarily affect glucose or energy balance in sensitive individuals.
While animal and early research data suggest a strong safety profile, large-scale long-term human studies remain limited.
Higher experimental doses may increase the likelihood of transient metabolic adjustments, though significant toxicity has not been widely reported in research setting
Observed effects in research settings appear to be dose-dependent and generally transient, resolving after the peptide’s active metabolic window.
Independent laboratory testing confirms purity and composition
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