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CJC-1295 with Dac

$150.00

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This modified GHRH analog is designed to stimulate endogenous growth hormone release while extending circulating half-life through the Drug Affinity Complex (DAC) modification. By enhancing plasma protein binding, it may provide prolonged activity compared to unmodified versions. Researchers investigate it for its potential to support sustained growth hormone signaling and metabolic regulation.

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1 $150.00
3 53.33 % $70.00
6 56.67 % $65.00
12+ 60 % $60.00

99%+ Purity Tests

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Free bacteriostatic water with every order.

Overview

Research suggests CJC-1295 with DAC may enhance endogenous growth hormone secretion and support anabolic signaling in laboratory studies. This synthetic peptide contains 29 amino acids and is designed as an analog of growth hormone–releasing hormone (GHRH). It is engineered to activate somatotroph cells in the pituitary gland.

Structural modifications, including substitutions of four amino acids, are believed to improve peptide stability while preserving receptor affinity.

The addition of the Drug Affinity Complex (DAC) includes a lysine derivative attached to the C-terminus. This modification is thought to extend circulating half-life by increasing plasma protein binding.

Preclinical research indicates this may prolong activity for several days. It also helps maintain functional interaction with GHRH receptors.

Use our Research Peptide Storage Guide — Laboratory Use Only — to ensure proper handling and stability for controlled experimental applications. Not for human consumption, therapeutic, or diagnostic use.

Key Characteristics

Molecular Details

  • Chemical Formula: Sequence-dependent (modified growth hormone–releasing peptide analogue with DAC conjugation)

  • Molecular Weight: ~4,000–5,000 g/mol (varies based on modification and DAC attachment)

  • CAS Number: Research designation / Assigned upon structural registration

  • Structure: Synthetic analog of growth hormone–releasing hormone (GHRH) conjugated with Drug Affinity Complex (DAC) technology to extend plasma half-life

Product Information

  • Form: Lyophilized peptide powder

  • Solubility: Soluble in sterile water or buffered aqueous solution

  • Stability: Stable when frozen; prolonged activity after reconstitution due to DAC modification

  • Half-Life: Extended half-life (days to approximately one week) compared to non-DAC variants

  • Storage: Store refrigerated at 36–46°F (2–8°C); protect from light and moisture

How It Works

A long-acting growth hormone–releasing hormone (GHRH) analog bound to a Drug Affinity Complex (DAC) designed to sustain endogenous growth hormone release and extend anabolic signaling.

Primary Mechanisms

Sustained GHRH Receptor Activation

Binds to pituitary GHRH receptors and stimulates prolonged pulsatile growth hormone secretion

Extended Half-Life via DAC Binding

Drug Affinity Complex (DAC) binding increases circulatory stability and duration of action

IGF-1 Upregulation

Stimulates downstream insulin-like growth factor-1 production through endogenous GH release

Anabolic & Metabolic Enhancement

Supports protein synthesis, tissue repair, and metabolic regulation via GH-mediated pathways

Research Benefits

Prolonged Endogenous Growth Hormone Elevation

Studied for sustained increases in GH and IGF-1 levels compared to short-acting analogs

Body Composition Research

Investigated for improvements in lean mass support and reduction in adiposity markers

Recovery & Tissue Regeneration

Explored for enhanced repair signaling in musculoskeletal and connective tissue models

Metabolic Function Support

Evaluated for improved metabolic efficiency and lipid utilization in research settings

Research Findings

Laboratory investigations have provided valuable insights into CJC-1295’s biological activity and research applications.

Growth Hormone & IGF-1 Response

Clinical and preclinical data indicate:

  • Significant elevation in pulsatile GH release

  • Sustained increase in IGF-1 levels

  • Dose-dependent endocrine response

Body Composition Effects

Studies demonstrate:

  • Increased lean muscle mass markers

  • Reduced fat mass in research models

  • Improved body composition over extended administration

Metabolic & Tissue Effects

Evidence suggests:

  • Enhanced protein synthesis signaling

  • Improved connective tissue repair markers

  • Increased collagen production in tissue models

Endocrine Observations

Research shows:

  • Minimal suppression of natural GH pulsatility when used appropriately

  • Stable pituitary responsiveness over repeated dosing cycles

  • Hormonal effects persist due to extended half-life

Potential Side Effects in Research

Safety considerations and tolerability profile observed in research settings.

Generally Well Tolerated

Temporary fluid retention, joint stiffness, mild injection site irritation

Common Observations

Temporary abdominal bloating, mild gastrointestinal discomfort

Metabolic Adjustments

Transient increases in blood glucose in sensitive individuals

Monitoring Recommended

IGF-1 levels, fasting glucose, blood pressure, fluid retention markers

Dosing is generally individualized and may require gradual titration

References

THIRD-PARTY LAB TESTED

Certificate of Analysis

Independent laboratory testing confirms purity and composition

99.614%

Purity

43ABF

Batch

February 2026

Date

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